[A Controlled Clinical Study Between Hepatic Arterial Infusion With Embolized Curcuma Aromatic Oil and Chemical Drugs in Treating Primary Liver Cancer]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Mar;21(3):165-7.
[Article in Chinese]

Abstract

Objective: To evaluate the effectiveness, toxicity and prospective application of hepatic arterial infusion (HAI) with Embolized Curcuma Aromatic oil (CAO) in treating primary liver cancer (PLC).

Methods: In the treated group, 32 patients with PLC were treated by HAI with 1-3 ml of embolized CAO and oral administration of Chinese herbal medicine. In the control group, 32 patients with PLC were treated with transcatheter artery chemoembolization (TACE).

Results: In the treated group, one patient attained complete remission (CR) and 13 partial remission (PR), the total effective rate being 43.75%. The level of alpha fetal protein (AFP) turned to normal range in 7 cases and decreased in other 7. In the control group, 10 obtained PR and the total effective rate being 31.25%, AFP level turned to normal in 5 and decreased in 2. There was no statistical significance between the two groups. The incidences of post-embolism syndrome, such as fever, abdominal pain and vomiting were similar between the two groups but no myelosuppression occurred in the treated group with significant difference (P < 0.01) as comparing with that in the control group. The mean survival time, median survival time, 1-, 2- and 3-year survival rate in the treated group was 11.5 months, 10 months, 37.5%, 13.3% and 6.9% respectively, while in the control group was 7.25 months, 6 months, 15.6%, 3.2% and 0 respectively. The treated group was better in mean survival time, median survival time and 1-year survival rate than that of the control group (P < 0.05).

Conclusion: HAI with embolized CAO showed a similar favorite effect in treating PLC as that of TACE, but superior than TACE with longer survival time and milder myelosuppression.

Publication types

  • Comparative Study
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Carcinoma, Hepatocellular / therapy
  • Case-Control Studies
  • Chemoembolization, Therapeutic*
  • Curcuma* / chemistry
  • Drugs, Chinese Herbal / administration & dosage*
  • Female
  • Hepatic Artery
  • Humans
  • Liver Neoplasms / therapy*
  • Male
  • Middle Aged
  • Oils, Volatile / administration & dosage*
  • Oils, Volatile / isolation & purification
  • Phytotherapy*

Substances

  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Oils, Volatile