[Clinical study on treatment of middle-advanced stage liver cancer by combined treatment of hepatic artery chemoembolization with gan'ai no. I and no. II]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Mar;21(3):168-70.
[Article in Chinese]


Objective: To observe the clinical effect of combined treatment of hepatic artery chemoembolization (HACE) and Chinese herbal medicine (CHM) in treating middle-advanced stage liver cancer.

Methods: Sixty patients with middle-advanced stage liver cancer were randomly divided into two groups. The 30 patients in Group A were treated with combined HACE and Chinese herbal medicine (Gan'ai No. I and No. II) and the other 30 in Group B were treated with HACE alone. All patients were followed up for over 3 years.

Results: The 0.5-, 1- and 2-year survival rate in Group A was 76.7%, 56.7% and 30.0% respectively, and those in Group B was 50.0%, 33.3% and 16.7% respectively. The 1- and 2-year recurrence rate in Group A was 43.3%, 66.7% and that in Group B was 66.7%, 90.0% respectively. Moreover, Group A was significantly superior to Group B in tumor shrinking, AFP decreasing and blood leucocyte reducing (P < 0.01), as well as in improving clinical symptoms.

Conclusion: The combined treatment has obvious effect in treating middle-advanced stage liver cancer.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Carcinoma, Hepatocellular / therapy
  • Chemoembolization, Therapeutic*
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Doxorubicin / administration & dosage
  • Drugs, Chinese Herbal / administration & dosage*
  • Female
  • Fluorouracil / administration & dosage
  • Hepatic Artery
  • Humans
  • Liver Neoplasms / therapy*
  • Male
  • Middle Aged
  • Phytotherapy*


  • Drugs, Chinese Herbal
  • Doxorubicin
  • Cisplatin
  • Fluorouracil