[Clinical study on post-operational anti-metastasis effect of xiaoliu pingyi mixture]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 May;21(5):335-8.
[Article in Chinese]


Objective: To observe the effect of combined use of chemotherapy (CT) and Xiaoliu Pingyi Mixture (XLPYM) in anti-metastasis, anti-relapse and tumor inhibition in patients after surgical operation.

Methods: Nienty-six patients of common tumor after operation were divided into 2 groups, the 58 patients in the observed group treated with CT plus XLPYM and the 38 patients in the control group treated with CT alone. After 2 courses of treatment, the status of 1 year remote metastasis and in local relapse of tumor were observed. For patients of relapse or metastasis, another 2 courses of treatment was given, then the changes of tumor size, quality of life, body weight, peripheral blood cells, immunity and hemorrheology were estimated and compared between the two groups.

Results: The remote metastatic rate and local relapse rate in the observed group were lower than those in the control group significantly (8.62% vs 44.74% and 15.52% vs 60.53%, P < 0.01). For patients of metastasis or relapse, the effective rate in the observed group was 46.24% and that in the control group was 24.00%, showing significant difference between the two groups (P < 0.05). Clinical observation also displayed that XLPYM could elevate the quality of life, regulate the disordered T-lymphocyte subsets, improve the hemorrheologic character and reduce the toxic-adverse reaction of CT in patients.

Conclusion: XLPYM in combining with CT has effects of tumor inhibition, anti-metastasis and anti-relapse in treating patients of common tumor in post-operational period.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / surgery
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / surgery
  • Male
  • Middle Aged
  • Neoplasm Metastasis / prevention & control*
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Phytotherapy*
  • Postoperative Period
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery


  • Drugs, Chinese Herbal