Tin: a potent inducer of heme oxygenase in kidney

Science. 1976 Apr 2;192(4234):60-2. doi: 10.1126/science.1257757.

Abstract

Tin greatly enhances heme breakdown in kidney, thus impairing heme-dependent cellular functions, such as cytochrome P-450 mediated drug biotransformation. This novel action of the metal results from a potent induction effect on heme oxygenase, the enzyme that catalyzes heme oxidation in microsomes. The possible toxicological implications of this tin effect in the kidney merit further investigation.

MeSH terms

  • 5-Aminolevulinate Synthetase / biosynthesis
  • Animals
  • Cytochrome P-450 Enzyme System / metabolism
  • Enzyme Induction / drug effects
  • Heme / metabolism*
  • Kidney / drug effects*
  • Kidney / enzymology
  • Kidney / ultrastructure
  • Male
  • Microsomes / enzymology
  • Microsomes, Liver / enzymology
  • Mixed Function Oxygenases / biosynthesis*
  • Rats
  • Tin / pharmacology*
  • Tin / toxicity

Substances

  • Heme
  • Tin
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • 5-Aminolevulinate Synthetase