The role of complement and natural antibody in intestinal ischemia-reperfusion injury

Int J Immunopathol Pharmacol. 2003 Jan-Apr;16(1):1-8. doi: 10.1177/039463200301600101.


Activation of the complement cascade is central to many types of injury. Ischemia-reperfusion is an important example of such an event. Using intestinal ischemia-reperfusion as a model, we have further elucidated the importance and mechanism of this activation. Of novel importance is the evidence that natural antibody is a trigger for these events via recognition of self-antigen. In this article, we review the role of natural antibody and complement in intestinal ischemia-reperfusion injury. It is hoped that this study will ultimately lead to better understanding of these important modulators and their role in this type of injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Complement Activation / immunology*
  • Humans
  • Immunoglobulin M / metabolism
  • Immunoglobulin M / physiology*
  • Intestinal Mucosa / metabolism
  • Intestines / immunology*
  • Intestines / pathology
  • Isoantibodies / metabolism
  • Isoantibodies / physiology*
  • Reperfusion Injury / immunology*
  • Reperfusion Injury / metabolism
  • Reperfusion Injury / pathology


  • Immunoglobulin M
  • Isoantibodies