Response of a calcium sulfate bone graft substitute in a confined cancellous defect

Clin Orthop Relat Res. 2003 Jan;(406):228-36. doi: 10.1097/01.blo.0000030062.92399.6a.


Calcium sulfate, plaster of Paris, has a long clinical history for use as a bone graft substitute in various skeletal sites. The current authors examined the in vivo response of calcium sulfate pellets alone or in combination with autogenous bone graft in a bilateral critical-size distal femoral cancellous defect in an adult sheep model. New thick bone formation was seen in defects filled with calcium sulfate pellets alone. Increased immunostaining for bone morphogenetic protein-2, bone morphogenetic protein-7, transforming growth factor-beta, and platelet derived growth factor was seen in defects filled with calcium sulfate pellets alone and in combination with autograft. The local acidity during calcium sulfate resorption is proposed as a possible in vivo mechanism for this type of material.

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / metabolism
  • Bone Substitutes / therapeutic use*
  • Bone Transplantation
  • Calcium Sulfate / therapeutic use*
  • Femur / diagnostic imaging
  • Femur / injuries*
  • Femur / metabolism
  • Immunoenzyme Techniques
  • Platelet-Derived Growth Factor / metabolism
  • Sheep
  • Tomography, X-Ray Computed
  • Transforming Growth Factor beta / metabolism
  • Transplantation, Autologous
  • Wound Healing


  • Bone Morphogenetic Proteins
  • Bone Substitutes
  • Platelet-Derived Growth Factor
  • Transforming Growth Factor beta
  • Calcium Sulfate