[Study on the release mechanism of fenoprofen calcium from hydrophillic sustained-release matrix]

C S Zhao; Z G He; S M Cui; X Tang; R H Zhang

[Study on the release mechanism of fenoprofen calcium from hydrophillic sustained-release matrix]

Yao Xue Xue Bao. 2001 Jan;36(1):63-6.

[Article in Chinese]

Authors

C S Zhao¹, Z G He, S M Cui, X Tang, R H Zhang

Affiliation

¹ Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110015, China. zhaocs@hotmail.com

PMID: 12579864

Abstract

Aim: To study the release mechanism of fenoprofen calcium (FC) from hydroxypropylmethylcellulose (HPMC) matrices.

Methods: The release of FC and the erosion properties of hydrophillic matrices containing HPMC was examined at different paddle speed. The release mechanism of FC was further confirmed by evaluating the n value in Peppas equation.

Results: The results indicate that the release of FC and the erosion of matrices exhibit zero order kinetic equation, and it exhibits line relationship between them.

Conclusion: In the first 40 min, FC mainly released by diffusion and erosion from HPMC matrix, while it was controlled by the rate of tablet erosion after 50 min.

Publication types

English Abstract

MeSH terms

Delayed-Action Preparations / chemistry
Fenoprofen / chemistry*
Hypromellose Derivatives
Methylcellulose / analogs & derivatives*
Methylcellulose / chemistry

Substances

Delayed-Action Preparations
Hypromellose Derivatives
Methylcellulose
Fenoprofen