Hair cell regeneration in the inner ear: a review

Clin Otolaryngol Allied Sci. 2003 Feb;28(1):5-13. doi: 10.1046/j.1365-2273.2003.00658.x.

Abstract

Hair cell regeneration has been shown to occur in the inner ear of mammals. Specifically, it has been demonstrated in the vestibular system and not the organ of Corti. Recent evidence suggests that the degree of the regenerative response may be augmented pharmacologically. This review discusses the field of hair cell regeneration in fish, amphibians, birds and mammals, and the relationship of regeneration to functional recovery

Publication types

  • Review

MeSH terms

  • Amphibians
  • Animals
  • Auditory Threshold / physiology
  • Birds
  • Ear, Inner / physiology*
  • ErbB Receptors / genetics
  • ErbB Receptors / metabolism
  • Fibroblast Growth Factor 2 / genetics
  • Fibroblast Growth Factor 2 / metabolism
  • Fishes
  • Hair Cells, Auditory / pathology
  • Hair Cells, Auditory / physiology*
  • Hearing Loss, Noise-Induced / drug therapy
  • Hearing Loss, Noise-Induced / pathology
  • Mammals
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Fibroblast Growth Factor / genetics
  • Receptors, Fibroblast Growth Factor / metabolism
  • Recovery of Function
  • Regeneration / physiology*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Up-Regulation

Substances

  • RNA, Messenger
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factor 2
  • ErbB Receptors