Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas

Br J Haematol. 2003 Feb;120(3):488-91. doi: 10.1046/j.1365-2141.2003.04072.x.


An unusual course was observed in a patient with indolent T-prolymphocytic leukaemia (T-PLL) who subsequently developed mycosis fungoides (Mf), lymphomatoid papulosis (LyP) and cutaneous CD30+ anaplastic large cell lymphoma (ALCL). Polymerase chain reaction analysis demonstrated identical monoclonal T-cell receptor-beta and -gamma gene rearrangements in all the different clinical entities. Furthermore, cytogenetic studies revealed the same aberrant clone with trisomy of chromosome 8 in T-PLL and ALCL cells. This unique observation suggests that in T-PLL, the leukaemic cells might undergo secondary transformation, subsequently resulting in different phenotypes of cutaneous T-cell lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Disease Progression
  • Humans
  • Leukemia, Prolymphocytic / pathology*
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Male
  • Neoplastic Stem Cells / pathology*
  • Skin Neoplasms / pathology*