Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer

Lung Cancer. 2003 Feb;39(2):145-9. doi: 10.1016/s0169-5002(02)00441-5.


We measured and compared the levels of plasma monocyte-derived microparticles (MDMP) and platelet activation markers [plasma platelet-derived microparticles (PDMP), CD62P binding to platelets; plt-CD62P, CD63 binding to platelets; plt-CD63], to develop a better understanding of their potential contribution to vascular complications of lung cancer. The concentrations of MDMP and PDMP in lung cancer patients were significantly higher (P < 0.01) than those in normal subjects. Levels of plt-CD62P and plt-CD63 were significantly higher (P < 0.001 for each) in lung cancer patients than in controls. Levels of sE-selectin were also higher in lung cancer patients than in control subjects. MDMP correlated positively with plt-CD62P, plt-CD63, and PDMP with its relation to PDMP being particularly significant. The number of MDMPs and PDMPs are patients who are non-small cell lung cancer were significantly higher than that in small cell lung cancer patients. In addition, levels of sE-selectin were higher in non-small cell lung cancer than in small cell lung cancer patients. These findings suggest that elevated MDMPs may be a sign of vascular complication in lung cancer patients, particularly those who suffer from non-small cell lung cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annexin A5 / metabolism
  • Antigens, CD / metabolism
  • Biomarkers, Tumor / blood*
  • Blood Platelets / pathology*
  • Carcinoma, Non-Small-Cell Lung / blood
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Small Cell / blood
  • Carcinoma, Small Cell / pathology
  • E-Selectin / metabolism
  • Female
  • Flow Cytometry
  • Humans
  • Lung Neoplasms / blood*
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Monocytes / pathology*
  • Peripheral Vascular Diseases / diagnosis*
  • Platelet Activation / physiology*


  • Annexin A5
  • Antigens, CD
  • Biomarkers, Tumor
  • E-Selectin