Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster?

Exp Gerontol. 2003 Mar;38(3):227-30. doi: 10.1016/s0531-5565(02)00263-2.


The argument is presented here that, while there exists considerable correlative evidence supporting the oxidative stress hypothesis of aging, key experiments to test this hypothesis using Drosophila transgenics overexpressing Cu,Zn-SOD fall short in providing validation. In particular, significant life span extensions tend to be observed when the backgrounds of the control flies are relatively short-lived, suggesting that bolstering antioxidative defenses is only effective in compromised genetic backgrounds. Other shortcomings of the transgenic approaches adopted to date will be summarized.

MeSH terms

  • Animals
  • Copper*
  • Drosophila melanogaster / genetics
  • Life Expectancy
  • Longevity / genetics*
  • Oxidative Stress / genetics
  • Superoxide Dismutase / genetics*
  • Zinc*


  • Copper
  • Superoxide Dismutase
  • Zinc