Limitations of maintenance therapy for viral respiratory infection-induced asthma

J Pediatr. 2003 Feb;142(2 Suppl):S21-4; discussion S24-5. doi: 10.1067/mpd.2003.22.

Abstract

In asthmatic children with persistent symptoms, maintenance therapy with nedocromil sodium, inhaled corticosteroids, or montelukast is associated with a decreased rate of asthma exacerbations. The greatest benefit is seen with use of regular inhaled corticosteroids in preschool- or school-age children, in whom asthma exacerbations, the need for rescue oral corticosteroids, unscheduled urgent medical visits, and hospitalizations are all decreased by approximately 50%. However, maintenance therapy is not beneficial in children with intermittent respiratory virus-induced wheezing without persistent symptoms.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Administration, Inhalation
  • Adrenal Cortex Hormones / therapeutic use
  • Adrenergic beta-Agonists / therapeutic use*
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy*
  • Asthma / virology*
  • Child
  • Common Cold / complications
  • Common Cold / drug therapy
  • Common Cold / virology
  • Glucocorticoids / therapeutic use*
  • Humans
  • Leukotriene Antagonists / therapeutic use*
  • Respiratory Sounds
  • Respiratory Tract Infections / complications*
  • Respiratory Tract Infections / virology*

Substances

  • Adrenal Cortex Hormones
  • Adrenergic beta-Agonists
  • Anti-Asthmatic Agents
  • Glucocorticoids
  • Leukotriene Antagonists