Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation

Chem Commun (Camb). 2003 Jan 21;(2):266-7. doi: 10.1039/b210240d.

Abstract

The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimony / chemistry*
  • Antiparasitic Agents / chemistry*
  • Glutathione / analogs & derivatives*
  • Glutathione / chemistry*
  • Hydrogen-Ion Concentration
  • Oxidation-Reduction
  • Spermidine / analogs & derivatives*
  • Spermidine / chemistry*
  • Structure-Activity Relationship
  • Temperature

Substances

  • Antiparasitic Agents
  • trypanothione
  • Antimony
  • Glutathione
  • Spermidine