Return of the chalones

Dev Cell. 2003 Feb;4(2):143-4. doi: 10.1016/s1534-5807(03)00027-3.


Members of the TGFbeta superfamily play many roles in embryonic development and adult tissue homeostasis. Now recent work focused on growth and differentiation factors (GDFs) suggest that these TGFbeta-like molecules may also control organ size and may, in fact, be the long sought after chalones, or negative growth regulators.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division / physiology
  • Growth Inhibitors / physiology*
  • Humans
  • Transforming Growth Factor beta / physiology


  • Growth Inhibitors
  • Transforming Growth Factor beta