Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts

Mycoses. 2003 Feb;46(1-2):29-37. doi: 10.1046/j.1439-0507.2003.00838.x.

Abstract

In this study, 36 extracts derived from 29 plant species selected using an ethnobotanical approach were tested for antifungal activity against a taxonomically diverse group of 13 human pathogenic fungi. We compared the inhibitory characteristics of these plant extracts with those of the commonly used antifungals, amphotericin B and ketoconazole, and the plant-derived antifungal, berberine. Several plant extracts, notably those from Zingiber officinale (ginger) and Juglans cinerea (butternut), had pronounced antifungal activity against a wide variety of fungi, including strains that were highly resistant to amphotericin B and ketoconazole. Further exploration of Z. officinale as an antifungal is warranted as this species is generally regarded as safe for human consumption.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B
  • Antifungal Agents / pharmacology*
  • Fungi / drug effects*
  • Ginger / chemistry
  • Humans
  • Medicine, Traditional
  • Microbial Sensitivity Tests
  • Plant Extracts / pharmacology
  • Plants, Medicinal*

Substances

  • Antifungal Agents
  • Plant Extracts
  • Amphotericin B