Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy

J Neurol Neurosurg Psychiatry. 2003 Mar;74(3):373-5. doi: 10.1136/jnnp.74.3.373.

Abstract

The case is described of a 20-year-old man with adrenoleukodystrophy who showed right spastic hemiparesis and gait disturbance. Brain magnetic resonance imaging disclosed predominant involvement of the left corticospinal pathway. The clinical symptoms improved after bone marrow transplantation. Transcranial magnetic stimulation disclosed significant improvement in various parameters of central motor conduction.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenoleukodystrophy / diagnosis*
  • Adrenoleukodystrophy / drug therapy
  • Adrenoleukodystrophy / surgery*
  • Adult
  • Bone Marrow Transplantation / methods*
  • Drug Combinations
  • Efferent Pathways / physiopathology*
  • Electromagnetic Phenomena / methods
  • Erucic Acids / therapeutic use
  • Evoked Potentials, Motor / physiology
  • Humans
  • Magnetoencephalography / methods
  • Male
  • Neural Conduction / physiology*
  • Paresis / diagnosis
  • Paresis / etiology
  • Paresis / physiopathology
  • Treatment Outcome
  • Triolein / therapeutic use

Substances

  • Drug Combinations
  • Erucic Acids
  • Lorenzo's oil
  • Triolein