Evidence for an intrarenal beta receptor in control of renin release

Am J Physiol. 1976 Feb;230(2):410-8. doi: 10.1152/ajplegacy.1976.230.2.410.


Infusion of isoproterenol intravenously in normal dogs at rates of 0.10 or 0.018 mug/min per kg body wt increased renin secretion; at the lower infusion rate arterial pressure (AP) and renal blood flow (RBF) were unchanged. Isoproterenol was also infused into the renal artery in normal dogs at 0.10 mug/min per kg; renin secretion increased in association with an increase in RBF but AP was unchanged. Plasma K concentration was consistently decreased in all three of the above experiments and because hypokalemia is known to increase renin release isoproterenol was not infused intrarenally at the lower rate; the decrease in plasma K level precluded relating the entire response in renin release to isoproterenol. Intrarenal infusion of propranolol at 0.05 mg/kg per h in Na-depleted dogs decreased renin secretion whereas intravenous infusion at the same dose failed to alter renin release. Intrarenal infusion of propranolol at this rate in Na-depleted dogs with a denervated, nonfiltering kidney also decreased renin release. In contrast, intrarenal infusion of phentolamine or phenoxybenzamine in normal dogs failed to alter renin secretion in doses that blocked alpha-adrenergic receptors. These experiments provide strong evidence for an intrarenal beta-adrenergic receptor that mediates renin release, and it seems likely from the experiment in the denervated, nonfiltering kidney that the receptor is located in the juxtaglomerular cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Dogs
  • Dose-Response Relationship, Drug
  • Epinephrine / pharmacology
  • Heart Rate / drug effects
  • Isoproterenol / pharmacology*
  • Kidney / blood supply
  • Kidney Cortex / metabolism
  • Norepinephrine / metabolism
  • Phenoxybenzamine / pharmacology
  • Phentolamine / pharmacology
  • Potassium / blood
  • Potassium / urine
  • Propranolol / pharmacology
  • Regional Blood Flow / drug effects
  • Renin / metabolism*
  • Sodium / blood
  • Sodium / urine
  • Sympatholytics / pharmacology*


  • Sympatholytics
  • Phenoxybenzamine
  • Sodium
  • Propranolol
  • Renin
  • Isoproterenol
  • Potassium
  • Norepinephrine
  • Epinephrine
  • Phentolamine