Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots

Nat Genet. 2003 Mar;33(3):382-7. doi: 10.1038/ng1100. Epub 2003 Feb 18.


Recent studies of human populations suggest that the genome consists of chromosome segments that are ancestrally conserved ('haplotype blocks'; refs. 1-3) and have discrete boundaries defined by recombination hot spots. Using publicly available genetic markers, we have constructed a first-generation haplotype map of chromosome 19. As expected for this marker density, approximately one-third of the chromosome is encompassed within haplotype blocks. Evolutionary modeling of the data indicates that recombination hot spots are not required to explain most of the observed blocks, providing that marker ascertainment and the observed marker spacing are considered. In contrast, several long blocks are inconsistent with our evolutionary models, and different mechanisms could explain their origins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Chromosome Mapping
  • Chromosomes, Human, Pair 19 / genetics*
  • DNA / genetics
  • Evolution, Molecular
  • Gene Frequency
  • Genetic Markers
  • Haplotypes / genetics*
  • Humans
  • Linkage Disequilibrium
  • Models, Genetic
  • Polymorphism, Single Nucleotide
  • Recombination, Genetic*


  • Genetic Markers
  • DNA