Neurotransmission of cognition, part 1, Dopamine is a hitchhiker in frontal cortex: norepinephrine transporters regulate dopamine

J Clin Psychiatry. 2003 Jan;64(1):4-5. doi: 10.4088/jcp.v64n0101.

Abstract

Since the frontal cortex has a low density of dopamine transporters, dopamine has to be inactivated there by hitching a ride on the norepinephrine transporter of neighboring norepinephrine neurons.

MeSH terms

  • Brain / physiology
  • Cognition / physiology*
  • Dopamine / metabolism
  • Dopamine / physiology*
  • Frontal Lobe / metabolism
  • Frontal Lobe / physiology*
  • Humans
  • Neurons / physiology
  • Norepinephrine / physiology
  • Norepinephrine Plasma Membrane Transport Proteins
  • Symporters / physiology*
  • Synaptic Transmission / physiology*

Substances

  • Norepinephrine Plasma Membrane Transport Proteins
  • SLC6A2 protein, human
  • Symporters
  • Dopamine
  • Norepinephrine