When neurons form memories

Trends Neurosci. 2003 Mar;26(3):123-4. doi: 10.1016/S0166-2236(03)00023-7.


Although long-term memory is central among our cognitive functions, the search for a direct neurophysiological correlate to it has proven difficult. The formation of new memories depends on the hippocampus and adjacent cortex, but the final storage is thought to be in a widely distributed neocortical network. Recent experiments, using simultaneous recordings from hundreds of sites in monkey neocortex, have revealed the activation of such a distributed network -- probably reflecting the consolidation of long-term memory storage.

Publication types

  • Review

MeSH terms

  • Animals
  • Haplorhini
  • Hippocampus / physiology
  • Memory / physiology*
  • Neocortex / physiology*
  • Neurons / physiology*