Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible times

Magn Reson Imaging. 2002 Dec;20(10):721-31. doi: 10.1016/s0730-725x(02)00598-2.


A methodology is presented for extracting precise quantitative MT parameters using a magnetisation-prepared spoiled gradient echo sequence. This method, based on a new mathematical model, provides relaxation parameters for human brain in-vitro and in-vivo. The in-vivo parameters have been obtained from three different regions of normal white matter: occipital white matter, frontal white matter and centrum semiovale; two regions of normal grey matter: cerebral cortex and cerebellum, and from five regions with MS lesions. All this has been achieved using MT images collected within a timeframe that is clinically feasible. We hope that this new technique will shed light on the properties and dynamics of water compartments within the brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / anatomy & histology
  • Brain / pathology*
  • Humans
  • In Vitro Techniques
  • Magnetic Resonance Imaging* / methods
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / pathology