Complication rate and diagnostic yield of 515 consecutive ultrasound-guided biopsies of renal allografts and native kidneys using a 14-gauge Biopty gun

Eur Radiol. 2003 Mar;13(3):527-30. doi: 10.1007/s00330-002-1482-3. Epub 2002 Jun 15.


Our objective was to evaluate the safety and diagnostic efficacy of the ultrasound-guided renal biopsy procedure using an automated biopsy device (Biopty gun) with a 14-gauge needle. Five hundred fifteen consecutive ultrasound-guided renal biopsies performed in two large university hospitals were retrospectively reviewed. Three hundred forty-five biopsies were performed on renal allografts and 170 on native kidneys. The tissue specimen was adequate for histological evaluation in 95.3% of the cases (94.8% in the transplanted kidney group, 96.5% in the native kidney group). The overall complication rate was 12.2% and was significantly higher in the native kidney group (19.4%) than in the renal allograft group (8.7%). Major complications occurred in 2.7% of the cases (2.9% of the renal allografts and 2.4% of the native kidney biopsies), including one procedure-related death and the loss of the renal allograft in two other patients. Minor complications were noted in 9.5% of the biopsies and there were significantly more in the group of the native kidneys (17.1%) than in the group of the transplanted kidneys (5.8%). Renal biopsy with an automated device using a 14-gauge needle has a high tissue recovery rate, but it is associated with a small risk of serious complications.

Publication types

  • Comparative Study

MeSH terms

  • Biopsy, Needle / adverse effects*
  • Biopsy, Needle / instrumentation
  • Cohort Studies
  • Female
  • Hematoma / epidemiology
  • Hematoma / etiology*
  • Hematuria / epidemiology
  • Hematuria / etiology*
  • Humans
  • Incidence
  • Kidney Diseases / diagnostic imaging
  • Kidney Diseases / mortality
  • Kidney Diseases / pathology*
  • Kidney Transplantation / diagnostic imaging
  • Kidney Transplantation / mortality
  • Kidney Transplantation / pathology*
  • Male
  • Reference Values
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Survival Rate
  • Transplantation, Homologous / pathology
  • Ultrasonography