Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice

Infect Immun. 2003 Mar;71(3):1566-8. doi: 10.1128/IAI.71.3.1566-1568.2003.


In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Animals
  • Antibodies, Protozoan / biosynthesis
  • Chronic Disease
  • Giardia lamblia / immunology
  • Giardiasis / immunology*
  • Immunoglobulin A / biosynthesis
  • Interleukin-6 / genetics
  • Interleukin-6 / physiology*
  • Mice
  • Mice, Inbred C57BL
  • RNA, Messenger / analysis


  • Antibodies, Protozoan
  • Immunoglobulin A
  • Interleukin-6
  • RNA, Messenger