Marked improvement in left ventricular ejection fraction during long-term beta-blockade in patients with chronic heart failure: clinical correlates and prognostic significance

Am Heart J. 2003 Feb;145(2):292-9. doi: 10.1067/mhj.2003.105.


Background: Some patients with heart failure (HF) may have a marked improvement in left ventricular ejection fraction (LVEF) after long-term beta-blockade. We compared the clinical characteristics and the prognosis of these patients with those of other patients.

Methods: One hundred seventy-one patients with chronic HF were assessed before and after 9 to 12 months of maintenance therapy with metoprolol or carvedilol.

Results: Thirty-eight patients (22%) showed an increase in their LVEF >or=15 units (from 20% +/- 8% to 43% +/- 10%). Compared with the other patients (LVEF change from 21% +/- 7% to 26% +/- 9%, P <.0001 for differences between groups), these patients also had a greater decline in the left ventricular end-diastolic volume (from 175 +/- 74 mL/m(2) to 113 +/- 36 mL/m(2)) and in the right atrial, mean pulmonary artery, and pulmonary wedge pressures, with a greater increase in the cardiac index, stroke volume index, stroke work index, and maximal functional capacity. Their long-term prognosis was excellent, with a 2-year cumulative survival rate of 95%, versus 81% for the other patients, and a hospitalization-free survival rate of 73%, versus 50% for the other patients (all P <.05). By means of multivariate analysis, only the nonischemic cause of HF and the mean arterial pressure at baseline were independently associated with an increase of >or=0.15 in LVEF.

Conclusions: Patients who show a marked improvement in their LVEF after long-term beta-blockade have an excellent prognosis and have a high prevalence of nonischemic HF and a higher blood pressure at baseline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Carbazoles / therapeutic use*
  • Cardiomyopathy, Dilated / drug therapy
  • Cardiomyopathy, Dilated / physiopathology
  • Carvedilol
  • Female
  • Follow-Up Studies
  • Heart Failure / drug therapy*
  • Heart Failure / physiopathology
  • Heart Function Tests
  • Humans
  • Male
  • Metoprolol / therapeutic use*
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Prognosis
  • Propanolamines / therapeutic use*
  • Stroke Volume / drug effects*
  • Stroke Volume / physiology
  • Ventricular Dysfunction, Left / drug therapy
  • Ventricular Dysfunction, Left / physiopathology
  • Ventricular Function, Left / drug effects
  • Ventricular Function, Left / physiology


  • Adrenergic beta-Antagonists
  • Carbazoles
  • Propanolamines
  • Carvedilol
  • Metoprolol