The MYST family of histone acetyltransferases

Curr Top Microbiol Immunol. 2003;274:203-36. doi: 10.1007/978-3-642-55747-7_8.

Abstract

Multiple chromatin modifying proteins and multisubunit complexes have been characterized in recent years. Histone acetyltransferase (HAT) activities have been the most thoroughly studied, both biochemically and functionally. This review sums up the current knowledge on a specific group of proteins that is extremely well conserved throughout evolution, the MYST family of histone acetyltransferases. These proteins play critical roles in various nuclear functions and the control of cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyltransferases* / chemistry
  • Acetyltransferases* / classification
  • Acetyltransferases* / genetics
  • Acetyltransferases* / metabolism
  • Animals
  • Drosophila / enzymology
  • Gene Expression Regulation, Fungal
  • Histone Acetyltransferases
  • Histones / metabolism*
  • Humans
  • Mice
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Transcription, Genetic
  • Yeasts / enzymology

Substances

  • Histones
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases
  • KAT7 protein, human
  • KAT8 protein, human
  • Kat6b protein, mouse