Recoverin and rhodopsin kinase

Adv Exp Med Biol. 2002;514:101-7. doi: 10.1007/978-1-4615-0121-3_6.


The majority of proteins involved in vertebrate phototransduction are expressed specifically in photoreceptors. Recoverin and rhodopsin kinase are expressed primarily in retinal photoreceptors and they interact with each other in a Ca2+-dependent manner. This Ca2+-dependent interaction has been studied extensively in vitro. Experiments utilizing animal models and electrophysiological approaches have started to provide important insight regarding its invivo function. Recoverin can be viewed as a negative regulator of rhodopsin kinase in vertebrate phototransduction. This interaction imparts a negative feedback loop at the receptor level and may play an important role in light adaptation and in recovery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium-Binding Proteins / metabolism
  • Calcium-Binding Proteins / physiology*
  • Electrophysiology
  • Eye Proteins*
  • G-Protein-Coupled Receptor Kinase 1
  • Hippocalcin
  • Humans
  • Light
  • Lipoproteins*
  • Nerve Tissue Proteins*
  • Protein Kinases / metabolism
  • Protein Kinases / physiology*
  • Protein Structure, Tertiary
  • Recoverin
  • Signal Transduction


  • Calcium-Binding Proteins
  • Eye Proteins
  • Lipoproteins
  • Nerve Tissue Proteins
  • RCVRN protein, human
  • Recoverin
  • Hippocalcin
  • Protein Kinases
  • G-Protein-Coupled Receptor Kinase 1
  • GRK1 protein, human
  • Calcium