Abstract
Methanolic extract of P. amarus was found to have potential anti-oxidant activity as it could inhibit lipid peroxidation, and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 104 microg/ml and the concentrations needed to scavenge hydroxyl and superoxide radicals were 117 and 19 microg/ml respectively. The extract was found to reduce the blood sugar in alloxan diabetic rats at 4th hr by 6% at a dose level of 200 mg/kg body wt and 18.7% at a concentration of 1000 mg/kg body wt. Continued administration of the extract for 15 days produced significant (P < 0.001) reduction in blood sugar. On 18th day after alloxan administration values were almost similar to normal in the group taking 1000 mg/kg body wt.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antioxidants / therapeutic use*
-
Blood Glucose / metabolism
-
Diabetes Mellitus, Experimental / blood
-
Diabetes Mellitus, Experimental / drug therapy*
-
Dose-Response Relationship, Drug
-
Free Radical Scavengers / therapeutic use
-
Hydroxyl Radical / metabolism
-
Hypoglycemic Agents / therapeutic use*
-
In Vitro Techniques
-
Lipid Peroxidation / drug effects
-
Lipid Peroxides / blood
-
Male
-
Methanol / chemistry
-
Phyllanthus / chemistry*
-
Plant Extracts / therapeutic use*
-
Plant Leaves / chemistry
-
Plant Stems / chemistry
-
Rats
-
Rats, Wistar
-
Superoxides / metabolism
Substances
-
Antioxidants
-
Blood Glucose
-
Free Radical Scavengers
-
Hypoglycemic Agents
-
Lipid Peroxides
-
Plant Extracts
-
Superoxides
-
Hydroxyl Radical
-
Methanol