The induction of apoptosis by local anesthetics: a comparison between lidocaine and ropivacaine

Anesth Analg. 2003 Mar;96(3):755-6, table of contents. doi: 10.1213/01.ane.0000047201.85815.9d.

Abstract

This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.

Publication types

  • Comparative Study

MeSH terms

  • Amides / pharmacology*
  • Anesthetics, Local / pharmacology*
  • Apoptosis / drug effects*
  • Cell Survival / drug effects
  • Flow Cytometry
  • Humans
  • Jurkat Cells
  • Lidocaine / pharmacology*
  • Phosphatidylserines / metabolism
  • Ropivacaine

Substances

  • Amides
  • Anesthetics, Local
  • Phosphatidylserines
  • Ropivacaine
  • Lidocaine