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. 2003 Mar;88(2):F143-6.
doi: 10.1136/fn.88.2.f143.

Effect of a change in global metabolic rate on peripheral oxygen consumption in neonates

I A-A Hassan  1 , Y A Wickramasinghe, S A Spencer
Affiliations

Effect of a change in global metabolic rate on peripheral oxygen consumption in neonates

I A-A Hassan et al. Arch Dis Child Fetal Neonatal Ed. 2003 Mar.

Abstract

Aim: To evaluate the effect of an induced change in global metabolic rate on peripheral oxygen consumption (VO(2)) in healthy full term neonates.

Subjects and methods: Twenty four healthy full term neonates were studied. Peripheral VO(2) was measured by near infrared spectroscopy (NIRS) using arterial occlusion and measurement of the oxyhaemoglobin (HbO(2)) decrement slope. Global VO(2) was measured by open circuit calorimetry. Global and peripheral VO(2) were measured in each neonate before and after a routine bath. Abdominal and forearm skin temperatures were also recorded.

Results: Nineteen neonates completed the study. Global VO(2) increased by 30.7% (p = 0.001), and peripheral VO(2) by 23.1% (p = 0.001). A correlation between the fractional changes in global and peripheral VO(2) was apparent (r = 0.76, p = 0.001). Abdominal skin temperature decreased by 0.8 degrees C (p = 0.001), and forearm skin temperature by 0.6 degrees C (p = 0.04).

Conclusions: Measurement of peripheral VO(2) using NIRS with arterial occlusion is responsive to conditions that increase global metabolic rate. Any change in global VO(2) must be taken into consideration during the interpretation of peripheral VO(2) measurements in neonates.

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Figures

Figure 1
Figure 1
A typical trace showing the immediate rise in haemoglobin (Hb) and fall in oxygenated haemoglobin (HbO2) that occurs as a result of oxygen utilisation after arterial occlusion. In this case, there is a slow drift upwards of total haemoglobin (HbT), which must be less than 10% of the change in HbO2 for the occlusion to be valid.
Figure 2
Figure 2
Correlation between change in peripheral and global oxygen consumption (VO2) as a result of a bath (19 pairs). r = 0.76 (p < 0.001).
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