New insights into the diversity and function of neuronal immunoglobulin superfamily molecules

Annu Rev Neurosci. 2003;26:207-38. doi: 10.1146/annurev.neuro.26.041002.131014. Epub 2003 Feb 13.

Abstract

Immunoglobulin superfamily (IgSF) proteins are implicated in diverse steps of brain development, including neuronal migration, axon pathfinding, target recognition and synapse formation, as well as in the maintenance and function of neuronal networks in the adult. We provide here a review of recent findings on the diversity and the role of transmembrane and secreted members of IgSF proteins in the nervous system. We illustrate that the complexity of IgSF protein function results from various different levels of regulation including regulation of gene expression, protein localization, and protein interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Antibody Diversity
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / physiology
  • Drosophila Proteins*
  • Genes, Immunoglobulin
  • Immunoglobulins / chemistry
  • Immunoglobulins / classification
  • Immunoglobulins / genetics
  • Immunoglobulins / physiology*
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology
  • Nervous System / chemistry
  • Nervous System / immunology*
  • Neural Cell Adhesion Molecules / genetics
  • Neural Cell Adhesion Molecules / physiology
  • Neurons / chemistry
  • Neurons / classification
  • Neurons / immunology*
  • Qb-SNARE Proteins
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology
  • Signal Transduction
  • Species Specificity
  • Synapses / genetics
  • Synapses / metabolism

Substances

  • Arabidopsis Proteins
  • Drosophila Proteins
  • Immunoglobulins
  • Nerve Tissue Proteins
  • Neural Cell Adhesion Molecules
  • Qb-SNARE Proteins
  • Receptors, Cytoplasmic and Nuclear
  • beat-Ia protein, Drosophila
  • vesicle transport v-SNARE 11 protein, Arabidopsis