Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae

AIDS. 2003 Mar 7;17(4):625-8. doi: 10.1097/00002030-200303070-00019.


Gonorrhoea enhances the transmission of HIV through increased viral shedding and the increased probability of seroconversion among previously HIV-negative individuals. However, the mechanism(s) underlying these influences remain poorly understood. We demonstrated that exposure to Neisseria gonorrhoeae induces the nuclear factor kappa B-dependent transcription from the HIV-1 long terminal repeat in derivatives of the Jurkat CD4 T cell line. These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD4-Positive T-Lymphocytes / microbiology
  • CD4-Positive T-Lymphocytes / virology*
  • Gonorrhea / complications
  • HIV Infections / transmission*
  • HIV Long Terminal Repeat*
  • HIV-1*
  • Humans
  • Jurkat Cells / microbiology
  • Jurkat Cells / virology
  • Neisseria gonorrhoeae / physiology*
  • Transcription, Genetic*