Outbreak of Meningococcal Disease Caused by PorA-deficient Meningococci

J Infect Dis. 2003 Mar 1;187(5):869-71. doi: 10.1086/367899. Epub 2003 Feb 18.

Abstract

An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection.

MeSH terms

  • Adolescent
  • Adult
  • Bacterial Typing Techniques
  • Child
  • Child, Preschool
  • Disease Outbreaks*
  • Female
  • Humans
  • Male
  • Meningococcal Infections / epidemiology*
  • Meningococcal Infections / microbiology*
  • Molecular Sequence Data
  • Neisseria meningitidis, Serogroup C / classification*
  • Neisseria meningitidis, Serogroup C / genetics
  • Neisseria meningitidis, Serogroup C / isolation & purification
  • Netherlands / epidemiology
  • Porins / genetics
  • Porins / metabolism*
  • Sequence Analysis, DNA
  • Serotyping

Substances

  • Porins
  • porin protein, Neisseria

Associated data

  • GENBANK/AY166656
  • GENBANK/AY166657