Membrane domains in the secretory and endocytic pathways

Cell. 2003 Feb 21;112(4):507-17. doi: 10.1016/s0092-8674(03)00118-1.


Progress in identifying, characterizing, and localizing the constituents of distinct membrane bound compartments has revealed a new level of intracellular subcompartmentation. Proteins and lipids are not uniformly distributed in a given organelle, and subdomains are formed by a combination of hierarchical assembly processes and protein exclusion. Thus, functionally distinct specializations of a given organelle are physically segregated to a greater extent than previously believed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / physiology*
  • Endocytosis
  • Endoplasmic Reticulum / physiology*
  • Endoplasmic Reticulum / ultrastructure
  • Endosomes / physiology
  • Golgi Apparatus / physiology*
  • Humans
  • Models, Biological
  • Protein Structure, Tertiary
  • rab GTP-Binding Proteins / metabolism
  • trans-Golgi Network / physiology


  • rab GTP-Binding Proteins