Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia

Nat Neurosci. 2003 Mar;6(3):221-2. doi: 10.1038/nn1021.

Authors

Guilherme Lucas¹, Panu Hendolin, Tibor Harkany, Karin Agerman, Gustavo Paratcha, Carl Holmgren, Yuri Zilberter, Mikko Sairanen, Liliana Minichiello, Eero Castren, Patrik Ernfors

Affiliation

¹ Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden.

PMID: 12601381
DOI: 10.1038/nn1021

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesia*
Analgesics, Opioid / pharmacology
Animals
Brain Stem / drug effects
Brain Stem / metabolism*
Dose-Response Relationship, Drug
Genes, Dominant
In Vitro Techniques
Locus Coeruleus / drug effects
Locus Coeruleus / metabolism
Mice
Mice, Mutant Strains
Mice, Transgenic
Morphine / antagonists & inhibitors
Morphine / pharmacology*
Naloxone / pharmacology
Nerve Growth Factors / deficiency
Nerve Growth Factors / genetics
Nerve Growth Factors / metabolism*
Pain Measurement / drug effects
Phosphorylation / drug effects
Receptor, trkB / drug effects
Receptor, trkB / genetics
Receptor, trkB / metabolism*
Receptors, Opioid, mu / metabolism
Trigeminal Nucleus, Spinal / drug effects
Trigeminal Nucleus, Spinal / metabolism

Substances

Analgesics, Opioid
Nerve Growth Factors
Receptors, Opioid, mu
Naloxone
Morphine
Receptor, trkB
neurotrophin 4