Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia

Nat Neurosci. 2003 Mar;6(3):221-2. doi: 10.1038/nn1021.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesia*
  • Analgesics, Opioid / pharmacology
  • Animals
  • Brain Stem / drug effects
  • Brain Stem / metabolism*
  • Dose-Response Relationship, Drug
  • Genes, Dominant
  • In Vitro Techniques
  • Locus Coeruleus / drug effects
  • Locus Coeruleus / metabolism
  • Mice
  • Mice, Mutant Strains
  • Mice, Transgenic
  • Morphine / antagonists & inhibitors
  • Morphine / pharmacology*
  • Naloxone / pharmacology
  • Nerve Growth Factors / deficiency
  • Nerve Growth Factors / genetics
  • Nerve Growth Factors / metabolism*
  • Pain Measurement / drug effects
  • Phosphorylation / drug effects
  • Receptor, trkB / drug effects
  • Receptor, trkB / genetics
  • Receptor, trkB / metabolism*
  • Receptors, Opioid, mu / metabolism
  • Trigeminal Nucleus, Spinal / drug effects
  • Trigeminal Nucleus, Spinal / metabolism

Substances

  • Analgesics, Opioid
  • Nerve Growth Factors
  • Receptors, Opioid, mu
  • Naloxone
  • Morphine
  • Receptor, trkB
  • neurotrophin 4