Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
, 53 (3), 390-1

Seizure Exacerbation Associated With Inhibition of Progesterone Metabolism

Affiliations
Case Reports

Seizure Exacerbation Associated With Inhibition of Progesterone Metabolism

Andrew G Herzog et al. Ann Neurol.

Abstract

The reduced progesterone metabolite tetrahydroprogesterone is a potent positive modulator of GABA(A) chloride conductance that exerts powerful neuroinhibitiory and anti-seizure effects in animal models. Cyclic natural progesterone use may lessen seizure frequency in women with catamenial seizure exacerbation. We report a case in which efficacy was eliminated during concomitant treatment with a reductase inhibitor. The observation suggests that a reduced metabolite, rather than progesterone itself, was responsible for improved seizure control.

Comment in

Similar articles

See all similar articles

Cited by 38 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback