Lithium orotate, carbonate and chloride: pharmacokinetics, polyuria in rats

Br J Pharmacol. 1976 Apr;56(4):399-402. doi: 10.1111/j.1476-5381.1976.tb07449.x.


1 The pharmacokinetics of the lithium ion administered as lithium orotate were studied in rats. Parallel studies were carried out with lithium carbonate and lithium chloride. 2 No differences in the uptake, distribution and excretion of the lithium ion were observed between lithium orotate, lithium carbonate and lithium chloride after single intraperitoneal, subcutaneous or intragastric injections (0.5-1.0 mEq lithium/kg) or after administration of the lithium salts for 20 days in the food. 3 The findings oppose the notion that the pharmacokinetics of the lithium ion given as lithium orotate differ from lithium chloride or lithium carbonate. 4 Polyuria and polydipsia developed more slowly in rats given lithium orotate than in those given lithium carbonate or lithium chloride, perhaps due to an effect of the orotate anion.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Carbonates / metabolism
  • Carbonates / pharmacology
  • Chlorides / metabolism
  • Chlorides / pharmacology
  • Drinking Behavior / drug effects*
  • Kinetics
  • Lithium / metabolism
  • Lithium / pharmacology*
  • Male
  • Orotic Acid / metabolism
  • Orotic Acid / pharmacology
  • Rats
  • Stimulation, Chemical
  • Urination / drug effects*


  • Carbonates
  • Chlorides
  • Orotic Acid
  • Lithium