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, 9 (2), 246-50

B-virus (Cercopithecine Herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease

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B-virus (Cercopithecine Herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease

Jennifer L Huff et al. Emerg Infect Dis.

Abstract

Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (HSV). Most macaques carry B virus without overt signs of disease. However, zoonotic infection with B virus in humans usually results in fatal encephalomyelitis or severe neurologic impairment. Although the incidence of human infection with B virus is low, a death rate of >70% before the availability of antiviral therapy makes this virus a serious zoonotic threat. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death.

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References

    1. Gay FP, Holden M The herpes encephalitis problem. J Infect Dis 1933;53:287–303
    1. Sabin AB, Wright WM Acute ascending myelitis following a monkey bite, with the isolation of a virus capable of reproducing the disease. J Exp Med 1934;59:115–36 10.1084/jem.59.2.115 - DOI - PMC - PubMed
    1. Whitley RJ, Roizman B Herpes simplex virus infections. Lancet 2001;357:1513–8 10.1016/S0140-6736(00)04638-9 - DOI - PubMed
    1. Eberle R, Hilliard J The simian herpesviruses. Infect Agents Dis 1995;4:55–70 - PubMed
    1. Ohsawa K, Black DH, Sato H, Eberle R Sequence and genetic arrangement of the u(s) region of the monkey B virus (cercopithecine herpesvirus 1) genome and comparison with the u(s) regions of other primate herpesviruses. J Virol 2002;76:1516–20 - PMC - PubMed

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