Alcohol metabolism: role in toxicity and carcinogenesis

Alcohol Clin Exp Res. 2003 Feb;27(2):336-47. doi: 10.1097/01.ALC.0000052583.87673.37.


This article contains the proceedings of a symposium at the 2002 RSA Meeting in San Francisco, organized and co-chaired by Thomas M. Badger, Paul Shih-Jiun Yin, and Helmut Seitz. The presentations were (1) First-pass metabolism of ethanol: Basic and clinical aspects, by Charles Lieber; (2) Intracellular CYP2E1 transport, oxidative stress, cytokine release, and ALD, by Magnus Ingelman-Sundberg; (3) Pulsatile ethanol metabolism in intragastric infusion models: Potential role in toxic outcomes, by Thomas M. Badger and Martin J.J. Ronis; (4) Free radicals, adducts, and autoantibodies resulting from ethanol metabolism: Role in ethanol-associated toxicity, by Emanuele Albano; and (5) Gastrointestinal metabolism of ethanol and its possible role in carcinogenesis, by Helmut Seitz.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Dehydrogenase / genetics
  • Alcohol Dehydrogenase / physiology*
  • Alcoholic Intoxication / enzymology*
  • Animals
  • Cytochrome P-450 CYP2E1 / genetics
  • Cytochrome P-450 CYP2E1 / physiology*
  • Cytokines / blood
  • Ethanol / pharmacokinetics*
  • Ethanol / toxicity*
  • Gastrointestinal Neoplasms / enzymology
  • Gastrointestinal Neoplasms / etiology*
  • Humans
  • Oxidative Stress / physiology
  • Polymorphism, Genetic / genetics
  • Risk Factors


  • Cytokines
  • Ethanol
  • Alcohol Dehydrogenase
  • Cytochrome P-450 CYP2E1