Leptin resistance - or why leptin fails to work in obesity

Exp Clin Endocrinol Diabetes. 2003 Feb;111(1):2-7. doi: 10.1055/s-2003-37492.


In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Resistance
  • Humans
  • Hypothalamus / physiology
  • Leptin / pharmacology*
  • Leptin / physiology
  • Leptin / therapeutic use
  • Obesity / drug therapy*


  • Leptin