Statins can inhibit proliferation of human breast cancer cells in vitro

Exp Clin Endocrinol Diabetes. 2003 Feb;111(1):47-8. doi: 10.1055/s-2003-37501.

Abstract

The effect of five statins, i.e. atorvastatin, fluvastatin, lovastatin, pravastatin and simvastatin was investigated on the proliferation of the human breast cancer cell line MCF-7. All statins except of pravastatin were able to inhibit cell proliferation up to 90 % at a concentration of 50 micro M. Between the effective statins no significant difference was observed indicating a class-specific effect. These data suggest that statins may have clinical significance in the primary prevention of human breast cancer beyond their cholesterol-lowering effect. However, clinical proof must be awaited before drawing any further conclusions.

Publication types

  • Comparative Study

MeSH terms

  • Breast Neoplasms / pathology*
  • Cell Division / drug effects
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Mevalonic Acid / pharmacology
  • Tumor Cells, Cultured

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Mevalonic Acid