Recurrence of lymphangioleiomyomatosis after single lung transplantation: new insights into pathogenesis

Hum Pathol. 2003 Jan;34(1):95-8. doi: 10.1053/hupa.2003.50.


Lymphangioleiomyomatosis (LAM) is a rare disease found primarily in white women of childbearing age. The present study describes a case of recurrent LAM after single lung transplantation. Double-staining nonisotopic in situ hybridization, immunohistochemistry, and short tandem repeat loci analysis demonstrated that the recurrent LAM lesions originated from the recipient. The data strongly support that metastatic spread of LAM cells or migration of progenitor cells plays an important role in the pathogenesis of LAM.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • DNA, Neoplasm / analysis
  • Fatal Outcome
  • Female
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Lung Transplantation / adverse effects*
  • Lymphangioleiomyomatosis / etiology*
  • Lymphangioleiomyomatosis / genetics
  • Lymphangioleiomyomatosis / pathology
  • Minisatellite Repeats / genetics
  • Neoplasm Recurrence, Local / etiology*
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / pathology
  • Polymerase Chain Reaction


  • DNA, Neoplasm