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Comment
. 2003 Mar 4;100(5):2168-70.
doi: 10.1073/pnas.0530224100. Epub 2003 Feb 26.

The Further Redefining of Steroid-Mediated Signaling

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Free PMC article
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The Further Redefining of Steroid-Mediated Signaling

Stephen R Hammes. Proc Natl Acad Sci U S A. .
Free PMC article

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Figure 1
Figure 1
Model for early nongenomic signaling in steroid-induced oocyte maturation. (A) In the absence of steroid, both the classical (SR) and membrane steroid (mPR) receptors are expressed at or near the oocyte plasma membrane (left and center). In some species, mPR might also be constitutively signaling through Gαs and/or Gβγ, either autonomously or through stimulation by an unknown ligand (Lig?), to block maturation (right). (B) Addition of steroid could lead to any combination of the following: (i) Steroid-bound mPR might rapidly activate Gαi, resulting in a decrease in intracellular cAMP (center). mPR-mediated activation of the PI3K or MAPK pathways might also occur. (ii) Steroid binding to the constitutively activated mPR could shut off signaling, which would also lower intracellular cAMP (right). These inactivated receptors could even “switch classes” from Gαs to Gαi signaling, resulting in even greater reductions in intracellular cAMP. (iii) Steroid binding to membrane-associated classical receptors might be signaling independently or in concert with the mPR to promote signaling through Src, PI3K, and MAPK (left).

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