Ameloblastic sarcoma: pathogenesis and treatment with chemotherapy

Cancer. 1976 Apr;37(4):1673-8. doi: 10.1002/1097-0142(197604)37:4<1673::aid-cncr2820370410>3.0.co;2-t.

Abstract

A recurrent tumor in a young male demonstrates the progression of an ameloblastic fibroma to an ameloblastic sarcoma. Chemotherapy with Actinomycin D, Vincristine, and Cytoxan produced a complete response without evidence of recurrence 4 years after initiation of chemotherapy. The patient developed an aggressive malignant melanoma 1 year after all chemotherapy was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use*
  • Cyclophosphamide / therapeutic use
  • Dactinomycin / therapeutic use
  • Drug Therapy, Combination
  • Head and Neck Neoplasms / complications
  • Humans
  • Jaw Neoplasms / drug therapy
  • Jaw Neoplasms / pathology*
  • Jaw Neoplasms / surgery
  • Male
  • Melanoma / complications
  • Neoplasm Recurrence, Local
  • Neoplasms, Multiple Primary
  • Odontogenic Tumors / drug therapy
  • Odontogenic Tumors / pathology*
  • Odontogenic Tumors / surgery
  • Vincristine / therapeutic use

Substances

  • Antineoplastic Agents
  • Dactinomycin
  • Vincristine
  • Cyclophosphamide