[The elaboration, use and evaluation of eye-drops with autologous serum in corneal lesions]

Farm Hosp. Jan-Feb 2003;27(1):21-5.
[Article in Spanish]


Objectives: To expose the elaboration process, microbiological control and effectiveness of an eyewash prepared with the patient's serum, for the treatment of injure corneas of different etiology.

Method: It was edited an elaboration protocol and microbiological control, following the norms of correct elaboration picked up in the real Ordinance 175/2001. The clinical answer was valued objectively and subjectively.

Results: The eyewashes got ready under sterile conditions, using the patient's serum diluted to 20% with physiologic. None of the containers conserved in the Service of Pharmacy were contaminated, while the contamination in those already used, varied according to the patient. Of the eleven evaluated cases, six experienced a total recovery of its corneal lesions, three improved partially, and in the remaining ones the treatment was not effective.

Conclusions: The elaboration of the eyewash doesn't present technical problems if we have the appropriate equipment for the realization under sterile conditions. The contamination of the containers seems to be due to the inadecuate use by the patients. The results, in spite of the even scarce number of treated patients, justify the treatment in serious cases of dry eye and corneal ulceration.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Anti-Infective Agents / administration & dosage*
  • Anti-Infective Agents / therapeutic use*
  • Corneal Diseases / drug therapy*
  • Drug Compounding
  • Humans
  • Ophthalmic Solutions / administration & dosage*
  • Ophthalmic Solutions / therapeutic use*
  • Plasma*


  • Anti-Infective Agents
  • Ophthalmic Solutions