Mediastinal talcoma masquerading as thymoma

Ann Thorac Surg. 2003 Feb;75(2):568-9. doi: 10.1016/s0003-4975(02)04325-4.


We report a young woman with a large, calcified anterior mediastinal mass discovered 18 months following a left talc pleurodesis. The lesion was evaluated and treated as the thymoma or teratoma that it appeared to be, with excision by a transcervical approach. Pathologic examination revealed a giant talc granuloma. Awareness of such a possibility following talc pleurodesis may allow surgeons to avoid unnecessary mediastinal exploration, and its occurrence suggests that talc administration simultaneous with mechanical pleurodesis should be avoided.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Calcinosis / etiology
  • Female
  • Granuloma, Foreign-Body / diagnosis*
  • Granuloma, Foreign-Body / etiology
  • Granuloma, Foreign-Body / surgery
  • Humans
  • Mediastinum / pathology*
  • Pleurodesis / adverse effects*
  • Talc / adverse effects*
  • Thymoma / diagnosis*
  • Thymus Neoplasms / diagnosis*


  • Talc