Expansion of CD19(hi)CD21(lo/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia

Immunobiology. 2002 Dec;206(5):502-13. doi: 10.1078/0171-2985-00198.


Common variable immunodeficiency (CVID) is characterized by a severe hypogammaglobulinemia. While the clinical picture is dominated by recurrent respiratory and gastrointestinal infections, a subgroup of up to 30% of the patients develops additional autoimmune phenomena, including thrombocytopenia and autoimmune hemolytic anemia. So far no classification allowed a prediction of the coincidence of immunodeficiency and autoimmunity. Here, we propose the size of the peripheral CD19(hi)CD2(lo/neg) B cell pool as a marker for CVID patients with autoimmune cytopenia and splenomegaly. Interestingly similar B cell populations are also found in patients with SLE and may not only be an epiphenomenon of the disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, CD19 / immunology
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / immunology
  • B-Lymphocyte Subsets / immunology*
  • Cell Count
  • Child
  • Common Variable Immunodeficiency / blood
  • Common Variable Immunodeficiency / classification*
  • Common Variable Immunodeficiency / complications
  • Common Variable Immunodeficiency / immunology*
  • Female
  • Flow Cytometry
  • Humans
  • Leukopenia / etiology
  • Leukopenia / immunology
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Middle Aged
  • Phenotype
  • Receptors, Complement 3d / immunology
  • Splenomegaly / etiology
  • Splenomegaly / immunology


  • Antigens, CD19
  • Receptors, Complement 3d