The role of long-lived plasma cells in autoimmunity

Immunobiology. 2002 Dec;206(5):558-62. doi: 10.1078/0171-2985-00204.


Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoantibodies / biosynthesis
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Autoimmune Diseases / immunology
  • Autoimmunity*
  • Cell Survival
  • Cytokines / immunology
  • Humans
  • Immunologic Memory
  • Plasma Cells / immunology*


  • Autoantibodies
  • Cytokines