Abstract
The synthesis of fully [13C/15N] labeled pyrimidine nucleosides has been achieved from 13C-glucose and labeled nucleobases. The reaction scheme leads directly to the protected nucleosides without the need for the inversion of configuration of C-3 of 13C-glucose. This was achieved by an oxitative ring-opening reaction removing the carbon with the wrong configuration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon Isotopes
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Chemistry, Organic / methods
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Chromatography, Thin Layer
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Cyclization
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Glucose / chemistry*
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Indicators and Reagents
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Molecular Structure
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Nitrogen Isotopes
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Nuclear Magnetic Resonance, Biomolecular
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Pyrimidine Nucleosides / chemical synthesis*
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Structure-Activity Relationship
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Uracil / chemical synthesis
Substances
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Carbon Isotopes
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Indicators and Reagents
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Nitrogen Isotopes
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Pyrimidine Nucleosides
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Uracil
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Glucose