Nebulized naloxone gently and effectively reverses methadone intoxication

J Emerg Med. 2003 Feb;24(2):185-7. doi: 10.1016/s0736-4679(02)00723-0.


A 46-year-old woman presented to the Emergency Department with lethargy and respiratory depression after ingesting methadone. Initial oxygen saturation of 61% on room air did not improve with supplemental oxygenation. As venous access was initially unobtainable, naloxone was administered by nebulizer. Within 5 min oxygen saturation was 100% and mental status was normal. The patient did not develop severe withdrawal symptoms. Naloxone hydrochloride has been administered by various routes to treat opioid toxicity. Our report describes the successful use of nebulized naloxone for methadone toxicity.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Methadone / poisoning*
  • Middle Aged
  • Naloxone / administration & dosage*
  • Narcotic Antagonists / administration & dosage*
  • Narcotics / poisoning*
  • Nebulizers and Vaporizers*


  • Narcotic Antagonists
  • Narcotics
  • Naloxone
  • Methadone