The female reproductive tract is unique in its capacity to remodel constantly throughout adult life. Some of the remodelling events that occur naturally in the uterus, specifically menstruation, parturition, endometrial regeneration and uterine involution, have features in common with events of tissue injury and repair in other tissues, where they may occur after injury or in association with various pathologies. This review draws comparisons between the normally occurring tissue 'injury' and repair in the reproductive tract and that occurring elsewhere.